On the Canon 6D Mark II, the in-camera lens aberration correction settings affect the camera-generated JPEGs and previews, not the underlying RAW image data. So if you shoot RAW and edit in Lightroom, those camera settings generally do not change the actual RAW file you import.

For RAW workflow, it’s usually simplest to leave correction decisions to your RAW processor, such as Lightroom or Canon DPP, where you can apply lens profiles non-destructively and adjust them as needed.

So in practice:

• Shooting RAW + Lightroom: use Lightroom’s lens corrections.
• Shooting JPEG in-camera: the camera’s correction settings matter.
• Shooting RAW+JPEG: the JPEG may be corrected in-camera, while the RAW remains uncorrected.

One caveat noted in the discussion: this behavior is not universal across all camera/lens systems. Some newer lens designs in other systems may rely heavily on built-in correction for JPEG output, and some corrections may be harder or impossible to fully disable. But for your 6D Mark II RAW workflow, Lightroom or DPP is the relevant place to handle lens corrections.