Yes, but glass is harder to render as a pure silhouette because it transmits light. The most reliable approach is to control the lighting rather than rely only on camera settings.

A true silhouette is easiest if you keep direct light from shining through the sculpture while placing it against a much brighter background. In practice, use a flag or other opaque blocker to stop the main light source from hitting the back of the glass, and keep the background brightly lit. In a studio, put plenty of distance between the sculpture and background and light the background separately.

If your goal is mainly to show the shape with little or no internal detail, rim lighting may look better than a strict silhouette: light the sculpture from both sides so only edge highlights define its form against a dark background.

Because the glass is colored, a filter in the opposite color can help darken the transmitted light, especially if black and white output is acceptable. A polarizer might also help in some cases, though results can vary.

So: yes, it’s possible, but it usually takes careful lighting control, and rim lighting is often the more attractive solution for glass.