Yes—tethered shooting is one valid use, since images may be sent directly to a computer instead of a card. Another common reason is retail/demo use: it lets shoppers test a camera in a store, fire the shutter, and review the result without needing their own memory card. It can also be useful for a quick functional check of the camera before inserting or buying a card. Beyond that, there usually isn’t much practical benefit for normal shooting, which is why many photographers disable the setting to avoid accidentally taking photos with no card installed.