Generally, no—it’s not recommended to clean DSLR lenses with canned compressed air.

Main risks:

• The strong airflow can blow dust deeper into the lens/camera or move it from one problem area to another instead of removing it.
• Compressed gas can cool rapidly as it sprays, which may cause temporary frosting/condensation.
• Canned dusters may spit liquid propellant, and you do not want that residue on lens glass or inside the camera.

For lens cleaning, safer options are a manual rocket blower, a soft brush, and proper lens-cleaning tissue or microfiber with lens-cleaning solution when needed. Use the least aggressive method first, and avoid blasting high-pressure air into the camera body or lens openings.