Yes. A practical way to avoid touching the camera between bracket sets is to use Magic Lantern on the 5D Mark II. Community members note that it adds extended auto exposure bracketing, allowing up to 13 shots in one sequence, so you don’t need to change shutter speed partway through and risk shifting the camera.

Another option mentioned is using a smartphone remote-control app with the appropriate cable. That can help trigger the camera without physical contact and may simplify running bracketed sequences.

In general, the best way to reduce alignment problems is to avoid touching the camera at all during the full bracket, use a remote release, and let the camera complete the entire sequence in one run if possible.