Yes. Based on the reported fix, Lightroom Classic expects the path /Users/{username}/Documents to exist at launch. If that Documents folder is missing after relocating your home folder, Lightroom can crash immediately after the splash screen.

The solution is simply to make sure that /Users/{username}/Documents exists. Lightroom will create an empty Adobe folder there when it starts. This does not require moving your whole home folder back to the SSD, and it should not meaningfully affect storage use or performance if the folder is otherwise empty.

So the likely issue is not Lightroom "ignoring" the relocated home folder, but rather that it still relies on a standard Documents path being present.