Yes—moving from an Epson V350 flatbed to a dedicated 35mm film scanner can give a noticeable improvement, especially with 35mm.

Based on the comparisons and specs mentioned, the biggest likely gains are:

• better effective detail/sharpness on 35mm
• improved handling of dense shadows/highlights due to higher Dmax on some dedicated scanners
• cleaner scans and added convenience if the scanner includes ICE for dust/scratch removal

The V350 is a general-purpose flatbed, so while its quoted resolution is high, a dedicated film scanner is typically optimized for 35mm and can produce visibly better film scans in practice. The improvement is more likely to be meaningful than subtle if your main use is 35mm negatives/slides.

That said, the upgrade is not a pure win in every respect. A flatbed keeps the flexibility to scan larger originals and different formats, while a dedicated film scanner is more specialized. Also, C-41 negative film usually doesn’t demand extremely high Dmax, so the dynamic-range gain may be most noticeable on denser transparencies rather than all negatives.

In short: if you mainly scan 35mm and want the best image quality, a dedicated film scanner is likely worth it; if versatility matters more, the V350/flatbed approach still has advantages.