Yes—physically adapting a Canon EF lens to a Nikon F body for macro is possible, and the adapter will effectively add extension, so losing infinity focus is not a problem for close-up work. A simple adapter without optics should not reduce image quality by itself.

The main issue is control, not optics. Canon EF lenses use electronic aperture control, so on a Nikon body you generally cannot stop the lens down unless the adapter provides electronic control. Without that, the lens stays wide open, which is especially limiting for macro because depth of field becomes extremely thin.

You should also expect manual focus and stop-down metering. Some Nikon bodies may not meter properly unless they detect a lens, so chipped adapters are sometimes used.

Avoid adapters with corrective glass if possible: they are meant to restore infinity focus and usually hurt image quality.

So: feasible for macro, but not very practical unless you have a way to control the aperture electronically or use a workaround to preset the aperture on a Canon body first.