In general, a mirrorless camera like the Fujifilm X100F should be fine for this kind of use if it’s carried in a reasonably padded case and not subjected to hard drops or obvious abuse.

Mirrorless bodies have fewer moving parts than DSLRs because they don’t have a mirror mechanism, so they’re arguably less vulnerable to vibration-related issues. The X100 series may also benefit from being relatively light and having a fixed lens, which reduces stress compared with larger interchangeable-lens setups.

Cameras are typically more robust than many people assume, and normal outdoor activity such as hiking or biking with decent padding is not usually a problem. While any device can be damaged by severe shock, ordinary trail vibration in a backpack is unlikely to cause cumulative “micro damage” in a well-protected camera.

So: padded case, avoid major impacts, and it should be fine.