Yes. A heavy lens can put extra stress on the camera’s lens mount if you support the setup by the camera body instead of the lens. A good rule of thumb is: if the lens has a tripod collar/ring, treat the lens as the main part and the camera as the attachment. In practice, support and carry the combination by the lens, not by letting the camera body take the weight. When mounting on a tripod, use the lens’s tripod collar if it has one. This helps reduce strain on the mount and lowers the chance of damage.