In theory, yes — but in practice it’s usually difficult.

The biggest problem is parallax: because the cameras are separated from each other, nearby objects will shift relative to the background, making stitching errors much more likely. Panorama stitching works best when all images are taken from essentially the same viewpoint.

Coverage is another issue. To make a full 360×180 sphere, each camera would need an extremely wide field of view and still enough overlap with adjacent images for stitching. Four cameras at the roof edges may still miss parts of the scene, especially ground/sky coverage, unless you use very wide fisheye lenses. Even then, overlap and alignment can be tricky.

So while possible, it would likely be labor-intensive and unreliable unless the scene is distant and simple. For a practical solution, a single viewpoint is better — either one camera/lens setup designed for panoramas, or a dedicated 360 camera. Multi-camera spacing is more useful when you intentionally want stereo/depth capture for VR, not for the easiest standard panorama stitch.