A few practical differences commonly stand out when moving from Canon to Nikon:

• Control directions may feel reversed. If you’re used to Canon, Nikon can initially feel “backwards” for zoom/focus direction and some camera controls such as shutter/aperture dials and even the meter display. On higher-end Nikon bodies, some dial/meter directions can be customized.
• APS-C crop factor differs slightly. Nikon DX is typically 1.5x, while Canon APS-C is commonly 1.6x, so field of view changes a little when comparing similar bodies/lenses.
• Lens autofocus behavior can vary. Some Nikon-mount lenses without built-in focus motors may focus more slowly than Canon lenses you’re used to, especially compared with Canon USM lenses. This is worth checking if AF speed matters to you.
• Lens lineup differences. Expect a different lens ecosystem, and some users find Nikon’s selection smaller and pricing higher in certain categories.

In short, the biggest adjustment is muscle memory with controls, followed by understanding how Nikon body/lens combinations may affect autofocus performance and field of view.