Yes. In Hugin, overlapping images are blended according to their order in the project, so you can move the low-resolution images later in the list using the Up/Down controls in the Images tab.

You can also use the Mask tab to exclude parts of the low-resolution images from the final blend, so Hugin only uses them where they are actually needed. Be careful not to mask areas that exist only in those low-res shots, or you’ll create holes.

If Hugin still doesn’t give the result you want, another workaround is to export separate versions and combine them manually: hide the low-res images and export the high-res panorama, then export the low-res contribution separately and merge them afterward, or run enblend manually.