Do these FoCal results suggest a Canon 70-200mm f/2.8L IS II has an astigmatism or alignment problem?

Based on the community replies, those FoCal results do look suspicious if the test was performed correctly. A few borderline readings wouldn’t mean much, but consistently poor results that worsen as the lens is opened wider can indicate a lens alignment/decentering issue rather than normal variation.

However, FoCal results can also be skewed by poor test setup. If the camera and test chart weren’t perfectly aligned, the graph may reflect tilt in the setup instead of a fault in the lens.

If the issue is real, this is generally not something AF microadjustment or simple calibration fixes. It usually points to a mechanical/alignment problem that would require service.

The practical next step is to get an unbiased check from Canon or another qualified service center. If service finds the lens out of tolerance, then the buyer’s complaint is likely valid; if service says it is within spec, the test result alone isn’t strong proof of a defect.

So: unusual enough to investigate, but not conclusive without proper testing or a service evaluation.